Chondrocalcinosis means accumulation of calcium pyrophosphate crystals in connective tissues. This disease was formerly known as pseudogout due to its similarities with gouty arthritis. The primary reason for development of these calcium pyrophosphate crystals is unknown; however, various conditions are linked with chondrocalcinosis as causes.
Some of these causes include arthritis, hypothyroidism, diabetes, and hyperparathyroidism. Deficiency of minerals like magnesium is also known to cause chondrocalcinosis. Let us try to understand more about different causes of chondrocalcinosis.
Causes Of Chondrocalcinosis
Hyperparathyroidism And Chondrocalcinosis
Hyperparathyroidism means over secretion of parathyroid hormone by parathyroid glands. It can result from an adenoma or carcinoma of parathyroid glands. Chondrocalcinosis is commonly known to occur in individuals who have hyperparathyroidism. Hyperparathyroidism results in increased calcium levels in blood. The condition is known as hypercalcemia. This is the reason why individuals suffering from hyperparathyroidism have an increased risk of developing calcifications near joints causing chondrocalcinosis. Therefore, hyperparathyroidism can be considered as a related cause of chondrocalcinosis.
Arthritis And Chondrocalcinosis
Arthritis means inflammation of joints. It can affect different joints in human body. Calcification is one of the primary consequences of arthritis. This is the reason why arthritis is linked with chondrocalcinosis. Occurrence of chondrocalcinosis in patients with arthritis is relatively common.
Different forms of arthritis like gouty arthritis and osteoarthritis are linked with chondrocalcinosis. Inflammation and other musculoskeletal changes in arthritis may trigger the formation of calcium pyrophosphate crystals. This is the primary cause for association of chondrocalcinosis with arthritis.
Pituitary Gland Tumor And Chondrocalcinosis
Pituitary gland is a small gland inside human brain. It is responsible for secretion of primary hormones which control various functions in the human body. Abnormal hormone secretion from pituitary gland can result in medical conditions like hyperparathyroidism. As stated above, hyperparathyroidism has been related with chondrocalcinosis. Hyperparathyrodism is just one of many complications that can occur as a consequence of pituitary gland tumor. This kind of imbalance in human body can be regarded as an indirect cause of chondrocalcinosis.
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Hypothyroidism and Chondrocalcinosis
Hypothyroidism is a condition where thyroid gland does not produce sufficient amounts of thyroid hormone. Hypothyroidism is listed as one of the causes of hypercalcemia. Abnormal accumulation of calcium in blood stream, as stated above, can result in calcifications.
The mechanism of formation of calcium crystals in hypothyroidism can be similar to hyperparathyroidism. Hypothyroidism, however, results in insufficient production of thyroid hormone. Hypothyroidism is also an indirect cause linked with chondrocalcinosis. Direct relation between hypothyroidism and chondrocalcinosis is also not confirmed.
Hemachromatosis And Gout With Chondrocalcinosis
Hemachromatosis means abnormal accumulation of iron in blood stream. It causes red patches on body. This is one of the medical conditions which are associated with chondrocalcinosis. The direct relationship between these two disorders is unknown. However, the connection between hemachromatosis and chondrocalcinosis is based on studies which show increased occurrence of chondrocalcinosis in patients suffering from hemachromatosis. The symptoms of chondrocalcinosis and gout are very similar in appearance. Also, frequency of occurrence of chondrocalcinosis in patients with gout is relatively high. This is the basis on which the two diseases are associated.
There are no primary causes of chondrocalcinosis. The above-mentioned causes are linked due to their common occurrence with chondrocalcinosis.