Top 5 Causes Of Wegener’s Granulomatosis


Causes Of Wegener's Granulomatosis

Wegener’s granulomatosis is a disease in which blood vessels get inflamed and the flow of blood to various organs is restricted. It is also known as granulomatosis with polyangiitis. Due to the restricted flow of blood, upper respiratory tract, kidneys and lungs are affected. Not only this, other organs may also get affected due to this. It is not a common disease and is also not serious. Symptoms associated with Wegener’s granulomatosis include chest pain, nose bleeding, shortness of breath, soreness in skin, fever, swelling, inflammation and pain in sinus etc.

In the condition of Wegener’s granulomatosis, granuloma is produced around the blood vessels, which is a kind of inflammatory tissue. This condition can destroy the tissues also. If Wegener’s granulomatosis is not treated, it may lead to fatal condition due to kidney failure. It is better if it is diagnosed and treated at an early stage. The exact cause behind Wegener’s granulomatosis is not known.

Top Causes of Wegener’s granulomatosis


There is no exact cause found to be associated with Wegener’s granulomatosis but it is considered that it may be the result of inflammation aroused due to some kind of infection.


No specific type of infection has been identified to be associated with Wegener’s granulomatosis. Infection can be one of the triggering events for the development of Wegener’s granulomatosis. A prior infection can also result in symptoms of this disease.

Abnormal Immune System

Wegener’s granulomatosis is the result of affected immune system. Any event that triggers an abnormal reaction from the immune system aroused due to inflammation of tissues can lead to the development of Wegener’s granulomatosis. Due to this, inflammation of blood vessels occurs and granulomas are produced around the blood vessels. The abnormal immune system may be the result of an infection.

Abnormal Immune System

Age Factor

Age is one of the factors associated with the development of Wegener’s granulomatosis. It has been found that Wegener’s granulomatosis occurs mostly in the ages between 40 and 65.¬†Though it can occur at any age but has been found to be prevalent in mostly the middle aged groups. Also, whites are more prevalent to get affected with Wegener’s granulomatosis than blacks. Male as well as female both get affected with this disease equally.

Age Factor

Environmental Factors

Some scientists believe that environmental factors may be associated with Wegener’s granulomatosis. Toxic materials present in the environment can lead to infections. These infections can trigger the development of Wegener’s granulomatosis in the patients.

Enviormental Factor

The infections lead to the development of inflammation of skin tissues which can trigger symptoms of Wegener’s granulomatosis disease. Thus, environmental toxins are thought to be contributory factors behind the reason of Wegener’s granulomatosis.

Genetic Reason

Genetic predisposition is also considered to be one of the predictable causes of Wegener’s granulomatosis. It can be a combination of the events of genetic predisposition and exposure to environmental toxins that cause Wegener’s granulomatosis. It has been found that 50 percent of the patients suffering from Wegener’s granulomatosis had a prior infection before the development of this disease. The infection might have been caused due to any of the reasons.