Cogan’s syndrome is a disorder in which inflammation of cornea occurs. Other symptoms associated with Cogan’s syndrome include weight loss, fever, vomiting, hearing loss, fatigue, nausea, redness of eyes, dizziness etc. If Cogan’s syndrome is not treated, it can cause blindness and deafness. It is one of the types of autoimmune diseases which affect eye and ear.
It is a rare disease which is common in the persons of the ages of twenty and thirty. It may also affect arteries in other body parts like kidneys, skin and other organs etc. Cause of Cogan’s syndrome is still not known. The Cogan’s syndrome is most likely to occur in young adults and children. This disease is a combination of audio vestibular disturbance and interstitial keratitis.
Top Causes of Cogan’s Syndrome
Bacterial infection is considered to be one of the causes behind Cogan’s syndrome. Chlamydia pneumonia is the bacteria which is responsible for causing Cogan’s syndrome. This bacterium is also the cause behind Cogan’s syndrome. This bacterial infection occurs prior the Cogan’s syndrome disease and hence is thought to be the cause behind it.
But many of the patients suffering from Chlamydia pneumonia have not been found to develop Cogan’s syndrome. It has been observed from the laboratory studies that autoantibodies in the blood of patients of Cogan’s syndrome can attack tissue of inner ear.
It is believed that autoimmune disease may be the cause of Cogan’s syndrome. Other diseases may be associated with Cogan’s syndrome. These infectious diseases include influenza-like infections and Chlamydia infection.
Though there are no infectious agents associated with Cogan’s syndrome, but these infectious diseases have been found to act as precursors of Cogan’s syndrome. It is not clear whether autoimmune disease causes cellular or humoral immunity.
There may be a secondary disorder associated with Cogan’s syndrome in which iris of eye gets affected. This secondary disorder might have resulted from primary disorder involving the cells lining the cornea. It is also suggested by some scientists that Cogan’s syndrome may be one of the syndromes of different stages of a single disease.
Genetic Factors & Rheumatic Diseases
Genetic factors may be one of the causes behind Cogan’s syndrome. Different genes may play an important role in causing the disease. Researchers still do not believe that Cogan’s syndrome is a hereditary disease.
The Cogan’s syndrome may be a part of rheumatic diseases like rheumatoid arthritis, systemic lupus erythematosus and Sjogren’s syndrome etc. But it is still not certain that rheumatic diseases lead to Cogan’s syndrome as it has been found that some of the patients who suffered from Cogan’s syndrome did not have rheumatic diseases.
Reactions to Medicines & Other Factors
Reactions to certain medicines may also be the cause associated with Cogan’s syndrome. These are long term reactions including hepatitis B virus or hepatitis C virus. Other factors that can cause Cogan’s syndrome include various pathological and immunological factors. These include the presence of immunoglobulin G, infiltration of plasma cell, presence of lymphocytes and influence of immunosupressants etc.