CRMO or chronic recurrent multifocal osteomyelitis is a disease which commonly occurs in children, more commonly in girls than boys, in which bones swell. Although swelling or inflammation of the bone can be a process, yet the other conditions associated with it are pain and redness. Though it manifests itself in the form of redness and pain, it is not caused by any infection.
What happens in CMRO is that the normal bones are attacked by the immune system and that is how our immune system protects the body. Children in the age bracket of eight to fourteen years are more susceptible to this disease. Some common symptoms of chronic recurrent multifocal osteomyelitis are mentioned below.
Symptoms Of Chronic Recurrent Multifocal Osteomyelitis
Swelling Of Long Bones
The most common symptom of this disease is the swelling or inflammation that comes with it. Mostly occurring in long bones like areas near the ankles, wrist or knees, the swelling can also be associated with pain and can be found in other sites also like the pelvis and the collarbone. Along with swelling these areas can be difficult to move too.
What is associated with swelling in the bones is fever. This is a typical attack in which the body goes through an intense phase of fever, swelling and difficulty of movement of the bones, with proper medication and treatment options the period of this attack can be minimised. The period of these fever attacks can range from weeks to months. This periodic fever attack is one of the symptoms of chronic recurrent multifocal osteomyelitis.
Children with CMRO or chronic recurrent multifocal osteomyelitis also suffer from bone lesions. As a symptom bone lesions can be seen in children and is again associated with pain and fever. These bone lesions can be found in any part of the body. This disease is autoimmune, which means that once treatment is discontinued, the disease can relapse. Often found in children in the age group of eight to fourteen, sometimes, toddlers and middle aged patients can also be affected.
This is a manifestation of the CMRO in which patients, children are generally also found to have a disorder of the blood known as Dyserythropoitic anaemia. Children who suffer from this condition also suffer from shortness of breath, fatigue etc.
Majeed also manifests itself in the form of disorders of the skin. The mutations in the LPIN2 gene are considered to be the cause of Majeed and children can get this if both parents carry the gene mutation.
Another one of the symptoms of chronic recurrent multifocal osteomyelitis is skin manifestations. Children or adults suffering from CMRO or chronic recurrent multifocal osteomyelitis can also show signs of this disease in skin manifestations like psoriasis, pustules or acne.
It has been seen that these skin disorders can occur on the feet or the hands of the patients. Parents who have psoriasis or any other inflammatory diseases of the skin are found to be carriers of the Majeed syndrome.
After analysing the symptoms properly, a disease like CRMO or chronic recurrent multifocal osteomyelitis can be treated and in most cases the treatment can keep these symptoms at bay.