Antibody, also known as immunoglobin is used by our immune system to fight viral and bacterial infections. These are produced by a type of white blood cell known as plasma cell. In some people these antibodies may solidify or turn into a gel form blocking the blood vessels. This causes inflammation of blood vessels throughout the body.
People suffering from auto immune disease or hepatitis C are at a higher risk of developing this condition. In this article we will discuss various symptoms of this disease which may vary depending on the body regions that are affected by this condition.
Symptoms Of Mixed Cryoglobulinemia
Enlargement Of Spleen
Spleen is located under the rib cage and helps our body in draining out the infections. White blood cells are produced in the spleen. Spleen filters the abnormal cells and tissues from the blood as it passes through the spleen.
The presence of a large number of foreign bodies make it overactive and leads to its swelling. Normally an undetectable organ in its normal size, spleen begins to show a slight bulge under the rib cage.
Glomerular are the tiny pores in kidney that filter blood. Obstruction in them cause glomerular disease which is basically inflammation of kidneys. If it remains unchecked then this condition can lead to complete kidney failure. Glomerular disease leads to other blood related complications in the body as it remains impure due to impaired kidney function.
Vasculitis is inflammation of the blood vessels and when this inflammation spreads to skin, it is called skin Vasculitis. This condition leads to changes in the skin colour and texture.
One may experience red and purple bumps on the skin. Bruising of the skin, hives and itching is also widely reported. Skin may develop rashes and small dots that may appear in patches.
Cryoglobulinemia can cause fluid retention in the lungs which consequently leads to persistent coughing, wheezing and shortness of breath.
Apart from these symptoms, the blockage in blood vessels leading into lungs may also increase the pressure making them bleed in severe cases. Pain in the chest may also indicate issues around lungs including their inflammation.
Abdominal pain is caused due to various factors in this condition. First is enlargement of spleen which exerts pressure on the abdomen and pushes it.
The clogged blood vessels around abdomen is the second reason behind abdominal pain. This condition further leads to inability to have large meals and may eventually result in weight loss and weakness.
Since Cryoglobulinemia involves inflammation and blockages of arteries, this disease can lead to severe damage to nerves and nerve diseases. The obstruction in the blood vessels reduce the blood circulation to the peripheries of the body resulting into numbness in limbs and extreme weakness making it difficult for you to stand or even sit.
There is reduction in the strength of grasps. There might also be pain in the extremities. Apart from affect on the limbs, this condition can also damage the central nervous system sometimes severely handicapping the person from performing simple and routine tasks.